I is actinomycetes so a lot of

I  The resistance of
bacteria and fungi are developed in the last few years against antibiotic and many families
of antibiotic aren’t effective and the old families of antibiotic aren’t able to treat a lot of pathogenic infection  so we must find new ways
to discover new antibiotic has
powerful action against bacteria
and fungi to overcome the resistance of bacteria
and fungi  and the best way to find
new antibiotics is to
discover new microorganisms
able to produce new effective antibiotics
. The best source of
antibiotics is actinomycetes so a
lot of types of antibiotics in our life and common use in our life for most pathogenic infection are from actinomycetes.Actinomycetes are still novel sources of antibiotics so we have to find the new source of actinomycetes and new microorganisms as a new source of antibiotics (Thermophilic
actinomycetes ). Actinomycetes are still the important source for many drugs, herbicides,
insecticides and anti-parasitic compounds
particularly Streptomyces species( Williams,
1982; Haghighi et al., 2004).The resistance of pathogenic bacteria and fungi
are still a big problem in our life and
this back to in few last years the antibiotics can easily control on pathogenic microorganism but nowadays it is very difficult to control the
infection and this is a reason for resistance if antibiotics. In our study we try to find rare group of thermophilic
actinomycetes and study its microbial activity against pathogenic, (Wedberg 1966 )organisms and to
improve its production of
antimicrobial substance by studying
physiological and biochemical factors affected the growth of
actinomycetes and it’s antimicrobial production So the development of newer
antimicrobial drugs, the
polyene and non-polyene antimicrobials still one of  the most potent broad-spectrum antibiotics  available for clinical use. As a result of the continuing search for new polyenes and non-polyenes, as well as
the limitations of current production
methods, in our study, we isolate and  characterize thermophilic Streptomyces and it’s antimicrobial activity and the improvement of production, purification and identification of antimicrobial substance Aim of the
work: 1-    
Isolation and characterization of thermophilic
Streptomyces with antimicrobial activity
2-    Optimizing the production conditions and purification process of the bioactive antimicrobial agents.   undefined undefined undefined undefined undefined undefined undefined
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